Place a lightly oiled pan over medium high heat. Once hot add in the beef, garlic powder, onion powder, salt, and pepper. Cook until beef is totally browned and then remove from heat.
Now let's tackle the special sauce. In a bowl add the mayo, ketchup, mustard, chopped pickles, red wine vinegar, onion powder, and paprika. Stir and set aside.
In a large bowl add in the lettuce, onions, pickles, cheese, sesame seeds, ground beef, and sauce. Using a set of tongs toss salad. Serve immediately! How fun is that???